Steroid profiling by lc
Anabolic-androgenic steroids ('anabolic steroids') are structurally related to testosterone. Anabolic steroid use in women can cause significant cosmetic and reproductive changes (see box 2 ). In addition, these substances can have a negative effect on serum lipid parameters, liver function (particularly with 17-methylated steroids), glucose tolerance, and they can significantly increase the risk of cardiovascular disease and thrombotic events, including venous thromboembolism, stroke, and myocardial infarction (9). Basaria s, wahlstrom jt, dobs as. Clinical review 138: anabolic-androgenic steroid therapy in the treatment of chronic diseases. The development of primary and secondary sexual characteristics is stimulated by testosterone in vertebrate males, and these effects can be either organizational or activational in nature (norris 1997 ; hadley 2000 ). Organizational effects tend to occur early in development, and during a critical window of time, thereby resulting...